After observation for 4 weeks, the GBM tumor volume was significantly increased in a mouse injected with shZBTB7A-expressing U87 cells compared to that in the control mice, and the protein expression levels of ZBTB7A and EPB41L5 in GBM tumor tissues were inversely correlated (Fig. 6e). The gene discussed is EPB41L5; the disease is glioblastoma.