We found that 32 genes were highly expressed in hypopharyngeal cancer, and the high expression of 16 genes was associated with poor OS, including ACAD9, ERCC5, COL4A5, COQ2, EGFR, EIF2B3, ERCC2, GJA3, JAG1, LDLR, POLG, PROK2, RAD54B, RYR1, SDHA and TUBB3. Here, PROK2 is linked to hypopharynx cancer.