In addition, we found four sites not reported in dbSNP database, including two mutations in BIVM-ERCC5 (exon6: c.c640t: p.r214c), (exon14: c.c2002t: p.r668c), GJA3 (Exon2: c.c56t: p.t19m) and SPG7 (exon9: c.c1198t: p.r400w), which may be related to the occurrence and development of hypopharyngeal cancer. This evidence concerns the gene SPG7 and hypopharynx cancer.