Not only were many collagen genes overexpressed in tumor progression between T1 and T2 stages, but also the mRNA expression of these collagen genes, such as COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A2, and COL6A3, was highly positively correlated. This evidence concerns the gene COL3A1 and neoplasm.