Not only were many collagen genes overexpressed in tumor progression between T1 and T2 stages, but also the mRNA expression of these collagen genes, such as COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A2, and COL6A3, was highly positively correlated. The gene discussed is COL6A3; the disease is neoplasm.