In a cohort of 19 matched-pair diagnosis-relapsed AML patients (dbGaP accession phs001027)26, we correlated low IL1RN expression in RNA-Seq data from AML blasts with poorer prognosis (Supplementary Fig. S1B), and reduced expression of IL1RN at relapse versus diagnosis (Supplementary Fig. S1C). The gene discussed is IL1RN; the disease is acute myeloid leukemia.