Congruent with our findings in AML patients and IL-1rn-KO mice, low IL-1rn contributed to the biased myelopoiesis in NRAS-G12D+ mice through pathways at least partially dependent on NFκB activation, which was confirmed in two different mouse models, i.e. Mx1-Cre NRASG12D and Vav-Cre NRASG12D. Here, NFKB1 is linked to acute myeloid leukemia.