PI3K/AKT/mTOR is a frequent mutation pathway in IDH-wt GBM patients.108 In particular, mutations in PTEN and PIK3K genes108 lead to abnormal activity of the PI3K/AKT/mTOR pathway, promoting GBM cell viability, stem cell maintenance, and tumor formation.109 This may be linked to the complex and extensive molecular modulation of PI3K/AKT/mTOR. This evidence concerns the gene PTEN and glioblastoma.