Bevacizumab has been applied for rGBM with the approval of the US Food and Drug Administration (FDA).47,48 LGG correlates with a molecular phenotype, and oligodendrogliomas with IDH-mut and 1p19q codeletion possess the best prognosis, and then those with IDH mut and 1p19q intact, while those with IDH wild type have the worst prognosis. Here, IDH1 is linked to oligodendroglioma.