To further assess whether acinar cells contribute to ductal cells during pancreatitis, we injected caerulein intraperitoneally to Tnni3-Dre;CK19-CreER;IR1 mice to induce acute pancreatitis (AP), and collected pancreatic tissues 48 h (the acute pancreatitis phase) after injury for analysis (Fig. 6a). This evidence concerns the gene NISCH and alkaline phosphatase measurement.