Briefly, myeloid cells (LYZ+), lymphocytes (CD3D+), osteoclasts (ACP5+), endothelial cells (CLDN5+), perivascular-like cells (PVL) (RGS5+TAGLNhigh), cancer-associated fibroblasts (CAFs) (TAGLNlowACTA2+) and proliferative cells (MKI67+) were identified in the study (Figs. 1b; c; S2). This evidence concerns the gene CLDN5 and cancer.