SIGLEC10 and cancer: CD24 is a cancer stem cell marker that is critical for the maintenance, self-renewal, and differentiation of OS.45–47 Recently, CD24 was identified as a novel “don’t eat me” signal through the CD24-Siglec10 interaction in cancers.48 However, scant attention has been given to the role of CD24 in innate immune evasion in OS.