Further research found that the expression of salivary HOTAIR and PVT1 was pancreatic cancer-specific and significantly reduced after the curative pancreatectomy.129 Similarly, lnc-PCDH9–13:1 was significantly elevated in cancer tissues, plasma and saliva of hepatocellular carcinoma patients compared with healthy controls. This evidence concerns the gene HOTAIR and familial pancreatic carcinoma.