ART4 and neoplasm: They found fucose levels higher in both cancer samples than in healthy controls, providing preliminary assessment for early diagnosis of tumor.178 Yang et al. have validated the differential expression level of galactosylated N/O-linked glycans in saliva in patients with breast cancer compared with healthy controls, promoting the study for early-stage diagnosis.179 Similarly, they also found alterations of salivary glycoprotein N-glycan profiles could be potential biomarkers distinguishing breast cancer or benign breast diseases and healthy subjects.