In IBD, salivary exosomal PSMA7 plays a role in identifying IBD with healthy controls.256 Sun et al. confirmed the existence of BPIFA1, CRNN, MUC5B, and IQGAP either in salivary microvesicles or in exosomes between normal subjects and lung cancer patients.257 Additionally, neurodegenerative diseases were given much attention for saliva exosome biomarker discovery.258. This evidence concerns the gene CRNN and inflammatory bowel disease.