Although considered to be cancer-specific, lncRNAs are not that specific in noncancerous diseases.132 For instance, two cancer-associated lncRNAs, lncRNAs NEAT1 and MALAT1, were upregulated not only in cancer but also during noncancerous conditions such as SARS-CoV-2 infection.133 Thus, before the usage of salivary lncRNA detection in clinical applications, those biomarkers described above still require more validation studies with larger sample sizes in multi-centers. The gene discussed is MALAT1; the disease is cancer.