Besides, saliva and serum CRP level was highly correlated in pediatric patients with pneumonia (r = 0.679; P < 0.001).188 Similarly, Lin et al. observed a correlation of CRP levels between serum and saliva samples over time in septic neonates.189 A higher salivary concentration of CRP was also observed in adult patients with sepsis compared to patients without sepsis, though without statistical difference (P > 0.05).190 The capacity of salivary CRP as a biomarker for sepsis both in neonates and adults exhibited differences, which needs further validation and mechanisms exploitation. The gene discussed is CRP; the disease is Sepsis.