On July 20, 2022, Nature published three papers on ADAR1 regulating abnormal immune activation through the canonical A-to-I RNA editing pathway.1–3 The study by Nicholas et al. demonstrated that ADAR1 negatively regulates the activity of ZBP1, and ZBP1 can promote autoimmune diseases in the absence of ADAR1 Zα domain function.1 However, knockout of ZBP1 rescued the phenotypic changes caused by ADAR1 Zα domain loss-of-function. This evidence concerns the gene ZBP1 and autoimmune disease.