CASP8 and cancer: Analyzing a panel of human PDAC cancer cell lines towards their responsiveness to TRAIL-induced apoptosis, MiaPaca2 cells were identified as TRAIL sensitive while Panc1, PaTu8902, and Patu8988t cells were considered resistant, as demonstrated by differential induction of caspase-8 activity and cleavage of the caspase substrate PARP (Fig. 1A).