PRKCZ and infection: Upon M. tuberculosis infection, the rapid differential methylation of the enhancer region of PRKCZ (encoding protein kinase C (PKC) zeta) plays an important regulatory role in the transcriptional response to infection.[41,42]PLA2G6 encodes A2 phospholipase and activation of this enzyme is critically involved in the process of M. tuberculosis infection induced macrophage apoptosis.[43] Specific pathological mechanisms of these molecules in the PKC signaling pathway in DMTB warrant further investigation.