Uterine fibroids are common benign tumors in premenopausal women, derived from monoclonal cells of uterine smooth muscle and characterized by large amounts of extracellular matrix containing collagen, fibronectin, and proteoglycans.[13] The estimated cumulative incidence of uterine fibroids by the age 50 was > 80% for black women and nearly 70% for white women.[14,15] Even if fibroids are asymptomatic in about 50% of cases, indeed, 30% to 40% of patients refer symptoms and need medical and/or surgical treatment.[16]. The gene discussed is FN1; the disease is leiomyoma.