Moreover, RNA, protein, and image analysis of a 3D tetra-culture tissue model indicated that platelet stimulation produces a diseased extracellular matrix in high-grade serous ovarian cancer with the upregulation of EMT and extracellular matrix genes, and platelet activation of mesothelial cells is vital for stimulating cancer cell invasion.[67] The important role of TGF-β and LPA in extracellular matrix remodeling has been demonstrated by researchers. Here, TGFB1 is linked to cancer.