TLR9 and chronic hepatitis B virus infection: To continue our research on chronic hepatitis B,[22,31,32] real-time PCR, Luminex, and chromatin immunoprecipitation technology were adopted to investigate the relationship among TLR9 expression in PBMCs, secretion levels of the corresponding downstream inflammatory factors, and HBV load in patients with chronic hepatitis B receiving treatment with the Ta1 and entecavir combination from the aspects of clinical treatment and immune mechanism.