Additionally, it was also found that NF-κB p65 promotes the proliferation of synovial cells and inhibits their apoptosis, leading to synovial hypertrophy and proliferation and aggravating the destruction of joint structures.[32] Our study showed that XF significantly reduced NF-κB p65 expression in HFLS-RA cells compared to the model group, indicating that XF could inhibit the inflammatory reaction of RA. This evidence concerns the gene NFKB1 and rheumatoid arthritis.