The results showed that cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses ranked in the top 5, both in terms of average annual and total LCS over the last 3 years, and the article Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy was also ranked in the top 30 of the total LCS for the last 3 years. Here, CTLA4 is linked to neoplasm.