Both BNP and NT-proBNP levels increased significantly with age.[34,35] The prognostic value of BNP and NT-proBNP has been reported to be more significant in younger patients than in older patients.[36,37] Therefore, BNP levels may have different diagnostic abilities for CIN in patients of different ages. This evidence concerns the gene NPPB and cervical squamous intraepithelial neoplasia.