As can be seen from the forest plot (Figures 2–4), the combined estimates of brain natriuretic peptide for the prediction of CIN were as follows: sensitivity, 0.73 (95% CI: 0.67–0.78); specificity, 0.77 (95% CI: 0.71–0.82); positive likelihood ratio, 3.2 (95% CI: 2.52–4.07); negative likelihood ratio, 0.35 (95% CI: 0.29–0.43); diagnostic score, 2.21(95% CI: 1.83–2.59); diagnostic odds ratio, 9.10 (95% CI: 6.23–13.27). The gene discussed is NPPB; the disease is cervical squamous intraepithelial neoplasia.