Wu et al (2021) reported that the positive feedback loop of circGLIS3/miR-644a/PTBP1 promotes the malignant progression of non-small cell lung cancer.[24] Similarly, according to Li et al (2019), PTBP1 enhanced exon11a skipping in a human ortholog of mammalian enabled pre-mRNA, which promoted migration and invasion in lung carcinoma cells.[25] Further research should be conducted to explore the potential role of PTBP1 in the tumorigenesis of lung tumors. The gene discussed is PTBP1; the disease is lung carcinoma.