PTBP1 and cancer: PTBP1 is a shuttle protein that moves between the nucleus and cytoplasm.[22] In the nucleus, PTBP1 performs functions associated with alternative splicing and polyadenylation, whereas in the cytoplasm, it is involved in mRNA localization, stability, and translation.[23] In cancer, PTBP1 is primarily involved in glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration.[1] We found no pan-cancer studies of PTBP1 through our literature search.