The relatively clear inducements of uterine leiomyoma include Med12 gene mutation,[1–4] mitochondrial mutation,[5] p53 signal pathway abnormality,[6] etc. Estrogen and progesterone can accelerate the growth of uterine leiomyoma.[7] Progesterone receptors directly activated by progesterone can promote the proliferation of uterine leiomyoma, and selective progesterone receptor modulators can treat uterine leiomyoma.[8,9]. This evidence concerns the gene TP53 and Uterine leiomyoma.