IL6 and macrophage activation syndrome: IL-1 blockade appears to be more effective than IL-6 blockade in treating MAS, and intravenous immunoglobulins (IVIg) should be considered when IL-1 inhibitors are ineffective.[5] HLH/MAS is also treated with tacrolimus, rituximab, and plasmapheresis, in addition to the drugs listed above.[14]