TNF and cancer: Their anti-tumor efficacy is mainly reflected in 2 aspects: to regulate immune function and then resist the invasion of tumor cells by improving the levels of T and B lymphocytes, and macrophages and regulating the levels of cancer suppression-related cytokines, such as interleukin-2, interleukin-12, and tumor necrosis factor-α.[39] Song et al[40] showed that icariin from Epimedium, a yangtonic drug, can effectively regulate the tumor immunosuppression microenvironment.