TGFB1 and cardiovascular disorder: The most common illnesses seen aging society are cardiovascular disorders.[58] In point of fact, becoming older is a factor in the structural and functional deterioration of both the heart and the blood circulation system.[59] The EMT mechanism is critical in cardiac remodeling, myocardial fibrosis, and other pathologies that occur in HF, DCM, and myocardial infarction.[60,61] ASPN can be activated by EMT mechanisms induced by TGF-β to promote cardiac fibrosis.[62,63]