Briefly, collagen deposition and EMT are 2 of the most important pathological processes that are implicated in the pathogenesis of a wide variety of diseases, including cancer, bone and joint diseases, cardiovascular disease, keloid condition, PF, and others, and ASPN can interact with collagen-related proteins such as CAL3A1 and CAL1A1 via TGF-β, Wnt/β-catenin, Notch, and other pathways, hence participating in the EMT mechanism. This evidence concerns the gene ASPN and skeletal system disorder.