Researchers recommended that assessment of ovarian reserve should be performed for women with autoimmune disorders, such as Hashimoto thyroiditis, systemic lupus erythematosus (SLE), and type 1 diabetes mellitus (T1DM).[5] A number of predictors for ovarian reserve have been described, including concentration of baseline FSH (bFSH), estradiol, inhibin B, anti-Müllerian hormone (AMH), ovarian volume, and the antral follicle count (AFC).[6] Among these predictors, AFC, AMH and bFSH are typically used to evaluate ovarian reserve, and hence were principally discussed in this section. The gene discussed is FSHB; the disease is autoimmune disease.