PPP3CA and infection: [24,25] Furthermore, septic knee arthritis and periprosthetic infection after joint replacement caused by S gordonii have been reported.[26–28] The route of infection in these cases is presumed to be transient bacteremia.[26] Surface-associated adhesins are thought to play an important role in the pathogenicity, and genes encoding several of these proteins, such as collagen adhesion protein (CNA), cell wall-associated protein (WapA), Streptococcus surface protein A (SspA), C5a peptidase (Scp), IgA1 protease and enolase, have been identified as associated factors.[29]