Of note, 4 hub genes (CDH11, COL6A3, EDNRA, and SERPINF1) were strongly downregulated in BC tissues, which may be vital in uncovering the underlying mechanisms related to BC progression and provide more insights into its molecular pathogenesis in addition to defects in the signaling pathways of hub genes associated with the BC. The gene discussed is EDNRA; the disease is breast cancer.