Recent studies also revealed that macrophages enhance the tumorigenesis and increase aggressive clinical manifestations of BC.[51,52] GSEA showed that significant pathways for CDH11, COL6A3, EDNRA, and SERPINF1 include “MYC-TARGETS-V1,” “MYC-TARGETS-V2” and “OXIDATIVE-PHOSPHORYLATION” (Fig. 10). This evidence concerns the gene EDNRA and breast cancer.