AKT1 and bladder transitional cell carcinoma: Moreover, upon constructing the co-expression network, as well as identifying the hub genes via WGCNA, we revealed that genes within the co-expression module which are highly associated with clinical features of BLCA samples in TGCA (blue module) were enriched in: signal transduction, cell adhesion, P13K-Akt signaling pathway as well as ECM-receptor interaction by GO and KEGG analyses (Fig. 4).