Ginsenoside can activate ERS through the ATF4-CHOP-AKT1-mechanistic target of rapamycin kinase pathway to upregulate autophagic flux and induce autophagic death in NSCLC cells.[36] Guangsangon E is a Diels–Alder adduct isolated from mulberry leaves that activates UPR to induce cell autophagy and death in A549 human NSCLC cells.[37]. The gene discussed is ATF4; the disease is non-small cell lung carcinoma.