ERN1 and neoplasm: Chen et al found kushenol Z could promote apoptosis in A549 and NCI-H226 NSCLC cell line by upregulation CHOP and activate caspase-7 and caspase-12 to trigger ERS.[25] Evodiamine increases TRAF2, ASK1, and p-JNK levels and promotes apoptosis in A549 and NSCLC cells via the IRE1α-TRAF2-ASK1 signaling pathway.[26] Yang B et al found target ERS to inhibit tumor growth in Lewis lung cancer transplantation tumors in C57BL/6 tumor-bearing mice via the IRE1α-XBP1 pathway.[27]