Several adhesion molecules and markers are expressed when the endothelial lining is impaired; these markers include intercellular adhesion molecule-1, 2, vascular cell adhesion molecule-1 (VCAM-1), endothelial microparticles, E and P-selectin.[14–17] Most importantly, the expression of these markers on endothelial cells would suggest an endothelial cell injury; therefore, they can be used as ideal biomarkers for endothelial function and the evaluation of risk for CVD amongst T2D. This evidence concerns the gene VCAM1 and type 2 diabetes mellitus.