Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that the signaling pathways were mainly associated with renin-angiotensin system, renin secretion, hypertrophic cardiomyopathy, chagas disease, protein digestion and absorption, and diabetic cardiomyopathy (Fig. 4G and Table S9, Supplemental Digital Content, http://links.lww.com/MD/I199). Here, REN is linked to Chagas disease.