XPNPEP2 was one of the critical genes in thyroid cancer targeted by miR-222-3p,[53] and it was associated with lymph node metastasis in prostate and cervical cancers.[54,55] REEP6, an accessory protein, refined CXCR1-mediated cellular responses in lung cancer.[56] Serum ACE levels in IBD patients were lower than in healthy controls, regardless of the genotype of ACE.[57] SLC13A2 involved liver metastases in CRC patients with an upward trend.[58] Moreover, the expression of METTL3/14, WTAP, HNRNPA2B1 and FTO had significant differences between 3 geneCluster types. This evidence concerns the gene ACE and inflammatory bowel disease.