On October 2022, the patient came to our hospital again for partial polypectomy of the colorectum, during the operation, Colorectal polyps can be seen significantly decreased (Fig. 1d–f), review chest and abdomen enhanced CT “showed no intestinal tube dilatation and Colorectal polyps" (Fig. 2i–l), and CEA, CA199, AFP, and other tumor indicators were always normal. The gene discussed is AFP; the disease is polyp of large intestine.