The main differential diagnosis in our case included “aggressive” CD20-negative lymphomas with a plasmablastic morphology, namely ALK-positive large B-cell lymphoma and plasmablastic lymphoma, as well as a primary CD20-negative diffuse large B-cell lymphoma.[9,10] The first two lymphoma entities were unlikely as the plasmablastic proliferation was negative for ALK, EMA and Epstein-Barr encoding region in situ hybridization. This evidence concerns the gene ALK and lymphoma.