PLEKHO1 and diabetic kidney disease: yang et al found that Src enhances the binding of c-Cbl to casein kinase 2 interacting protein 1 (CKIP-1) by promoting c-Cbl phosphorylation and ultimately CKIP-1 protein expression was down-regulated.[26] However, it is interesting to note that CKIP-1 plays a nephroprotective role in the development of diabetic nephropathy.