Signal transducer and activator of transcription 3 (STAT3) plays a key role in regulating inflammation and the immune response.[25] STAT3 is activated by phosphorylation of tyrosine 705 and/or serine 727, and phosphorylated STAT3 can bind target sequences in promoter regions to regulate gene transcription.[26] Recently, elevated STAT3 levels in SLE have attracted increased attention. This evidence concerns the gene STAT3 and systemic lupus erythematosus.