The authors consider that these mechanisms involve aspects of treatment for cancer in addition to immunology.[7] Sonehara et al reported that higher GNRI was associated with better survival among patients with previously treated non-small cell lung cancer who were treated with immune checkpoint inhibitors, which might be related to that group having lower serum albumin levels.[31] We think that the presence of nutritional decline may not be suitable for TACE treatment again for poor nutritional status may be associated with hypoproteinemia and massive ascites. This evidence concerns the gene ALB and cancer.