In conclusion, TYROBP may have diagnostic and therapeutic potential for ccRCC.[23] The relationship between TYROBP and immune cell infiltration showed that the high expression of TYROBP was related to the high infiltration rate of immune cells, including B cells, CD8+T cells, CD4+T macrophages, neutrophils, and dendritic cells. This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.