Survival analysis showed that 8 downregulated hub genes (HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG, HMGCS2) and 2 upregulated hub genes (SERPINE1 and TYROBP) might be the essential genes of ccRCC. This evidence concerns the gene TYROBP and nonpapillary renal cell carcinoma.