The differentially expressed genes (DEGs) are mainly involved in glycolysis/gluconeogenesis, PPAR signaling pathway, complement, and coagulation cascade reactions.[24] This suggests that ccRCC is closely related to metabolism and immune regulation.[25] Many studies have shown that carcinogenesis may be closely associated with metabolism, confirming our research’s general direction. The gene discussed is PPARA; the disease is nonpapillary renal cell carcinoma.