Through network topology parameter screening, the key targets of Miaoyao Tongfengting Decoction in the treatment of gout are AKT1, TNF, ALB, IL6, TP53, VEGFA, EGFR, SRC, JUN, STAT3, IL1B, EGF, MAPK3, MYC, HSP90AA1, PPARG, HRAS, TLR4, PTGS2, IL10, MMP9, ERBB2, PTPRC. This evidence concerns the gene MAPK3 and gout.