Through network topology parameter screening, the key targets of Miaoyao Tongfengting Decoction in the treatment of gout are AKT1, TNF, ALB, IL6, TP53, VEGFA, EGFR, SRC, JUN, STAT3, IL1B, EGF, MAPK3, MYC, HSP90AA1, PPARG, HRAS, TLR4, PTGS2, IL10, MMP9, ERBB2, PTPRC. Here, PTGS2 is linked to gout.