The Forrest plot on IL-6 indicated the strong heterogeneity where the pooled estimate favoured the experimental group as indicated using two reports obtained.[27,32] This can be hypothesized that it is possible due to the research obtained from T2D, having elevated levels of IL-6.[38] Additionally, the meta-analysis for TNF-α using the obtained eligible reports indicated a slightly above average heterogeneity without much shift of the pooled estimate. This evidence concerns the gene IL6 and type 2 diabetes mellitus.