IGHE and allergic disease: Yuki et al found that NLRP3 polymorphisms (rs4612666 and rs10754558) were significantly associated with susceptibility to food induced allergic reactions and aspirin-induced asthma.[29] Another study revealed that the frequency of the CG genotype of NLRP3 rs10754558 was significantly increased in asthmatic patients with low IgE levels.[30] In this study, we analyzed the relationship between IgE levels and gene polymorphisms.