In the prediction results of this study, 12 of the first 20 lncRNAs associated with colorectal cancer had been already proved by relevant medicine: lncRNA XIST expedited metastasis and modulated epithelial-mesenchymal transition in colorectal cancer [49]; lncRNA SNHG16 promoted colorectal cancer cell proliferation, migration, and epithelial-mesenchymal transition through miR-124-3p/MCP-1 [50]; and lncRNA MALAT1 promoted the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation [51]. This evidence concerns the gene MALAT1 and colorectal cancer.