The pathogenesis of AD involves abnormal accumulation of Aβ, hyperphosphorylation of Tau protein, oxidative stress, inflammation, and immune abnormalities; with the deepening of research, new factors leading to the progression of AD are gradually being discovered (Sanabria-Castro et al. 2017), which indicated the complexity of AD pathogenesis leads to the lack of specific drugs in AD treatment. The gene discussed is MAPT; the disease is Alzheimer disease.