UBE3A and Angelman syndrome: The HERC2 gene encoding HECT domain and RCC1-like domain 2 can also be important because this E3 ubiquitin protein ligase interacts with UBE3A (Kühnle et al., 2011) and its loss-of-function causes a neurodevelopmental disorder with Angelman syndrome-like features (Puffenberger et al., 2012; Harlalka et al., 2013).