UBE3A and Angelman syndrome: The EEG power spectrum and sleep phenotypes of maternal Ube3a knockout mice directly correlate with those in Angelman syndrome patients, but about 70% of Angelman syndrome patients have a larger deletion in the chromosomal region 15q11–q13 that encompasses UBE3A and other genes with biallelic or paternal expression (Bird, 2014; Buiting et al., 2016).