GABRG3 and epilepsy: Particularly, the GABRB3, GABRA5, and GABRG3 genes in this region encode GABAA receptor subunit β3, α5, and γ3, respectively, and are likely to be critical given the vital role of GABAergic inhibition in brain functions and the fact that heterozygous loss-of-function GABRB3 variants cause a broad spectrum of epilepsies (Møller et al., 2017).