SNCA and early-onset autosomal dominant Alzheimer disease: Indeed, CASA boosting by HSPB8 or BAG3 overexpression or by pharmacological induction has been proven to decrease the accumulation of the microtubule-associated protein tau in Alzheimer disease, SNCA/α-synuclein in Parkinson disease, the extended polyQ stretch-containing proteins huntingtin and androgen receptor, causative of Huntington and spinal and bulbar muscular atrophy diseases, respectively.