CSN1S1 and amyotrophic lateral sclerosis: Also, CASA-mediated clearance was observed for SOD1 (superoxide dismutase 1) carrying the G93A mutation, the toxic C-terminal fragments of TARDBP, and the dipeptide repeats products that result from the non-canonical repeat-associated non-AUG (RAN) translation of the C9orf72 GGGGCC hexanucleotide expansion, which are linked to ALS-frontotemporal lobar degeneration [69,166,168–174].