The neuroprotective functions of STUB1 have been investigated in Parkinson disease, Alzheimer disease, ALS and several polyglutamine (polyQ) diseases and are mediated by the ability of STUB1 to form heterocomplexes with both HSPAs and HSPCs and to participate in substrate routing to both the proteasome and autophagy [159–165]. The gene discussed is STUB1; the disease is amyotrophic lateral sclerosis.