For example, multiple TAM subsets with distinct gene signatures, such as macrophage in the transitory state (with high LYZ, EREG, and S100A6 expression and low C1Q expression), microglia-like macrophage (with high BIN1, CX3CR1, TMEM119, and OLFML3 expression), hypoxic macrophage (with high BNIP3, ADAM8, FAM162A, and MIF expression), and phagocytic/lipid macrophage (with high FABP5, GPNMB, LGALS3, and CD63 expression), have been identified in GBM patient and mouse tumors (24). The gene discussed is OLFML3; the disease is glioblastoma.