For example, IBA1+TMEM119–CXCL3+ macrophages are predominantly located at perinecrotic areas and express genes involved in inflammatory program and glycolysis, whereas IBA1+TMEM119+CCL4+ microglia are enriched at the tumor-brain interface and express chemoattractant-encoding genes involved in T cell recruitment (110). This evidence concerns the gene CXCL3 and neoplasm.