Despite distinct transcriptional profiles and dynamics, macrophages and microglia in IDH-WT GBM display a similar expression pattern of genes (e.g., THBS1, TGFBI, FN1, and VCAN) that regulate extracellular matrix proteins (18), suggesting that different TAM subpopulations may cooperatively shape the TME in response to a certain genetic mutation. Here, TGFBI is linked to glioblastoma.