On the other hand, M2 polarization is triggered upon stimulation with antiinflammatory cytokines (e.g., IL-4, IL-10, or IL-13), and such polarized macrophages show less cytotoxicity on tumor cells via production of antiinflammatory cytokines, e.g., IL-10, TGF-β, CCL22, and CCL17 (48–50). This evidence concerns the gene IL10 and neoplasm.