In T2D mice, FGF21 can prevent T2DM lipotoxicity-induced cardiomyopathy by activating both the AMPK-ACC-carnitine palmitoyltransferase-1-mediated lipid-lowering pathway and the AMPK-Akt2-nuclear transcription factor-E2-related factor 2 (Nrf2)-mediated antioxidative pathway in the heart 110. The gene discussed is FGF21; the disease is type 2 diabetes mellitus.