SIRT3 and colorectal carcinoma: Next, we assessed the prognostic potential of PROX1 and SIRT3 expression in CRC and found that patients with low PROX1 and high SIRT3 expression had much better OS (P = 0.002) and DFS (P = 0.001) than patients with other combinations of PROX1 and SIRT3 expression (Figure 5H).