PROX1 and colorectal carcinoma: Moreover, analysis of the correlation of PROX1 levels with clinicopathological data for patients with CRC showed that high PROX1 expression was positively associated with tumor depth of invasion (P = 0.031), lymphatic metastasis (P = 0.001), TNM stage (P = 0.002) and Ki67 immunostaining (P = 0.049; Table 1).