SIRT3 and malignant colon neoplasm: Moreover, several studies have revealed that by being involved in mitochondrial function and antioxidant responses in colon cancer 40-43, SIRT3 promotes cancer cell viability, mobility and proliferation and contributes to chemoresistance in CRC, suggesting that the SIRT3 gene harbors pro-tumorigenic properties and can behave as an oncogene.