Multivariate Cox proportional hazards analysis revealed that histologic grade (HR 1.447, P = 0.022), lymphatic metastasis (HR 3.906, P = 0.000) and PROX1 IHC score (HR 2.275, P = 0.008) were independent prognostic factors for OS in CRC patients (Table 2). The gene discussed is PROX1; the disease is colorectal carcinoma.