HK1 and colorectal carcinoma: Then, we investigated whether the effects of PROX1 on cell proliferation and glucose metabolism in CRC cells were mediated by SIRT3. The results showed that SIRT3 knockdown (Supplementary Figure 4A) partially restored the growth (Figure 5A-C), capacity for glycolysis (Figure 5D-F) and mRNA level of glycolytic enzymes (Supplementary Figure 4B) of PROX1-knockdown HCT116 and SW480 cells in vitro and in vivo.