Analysis of the correlation of EZH2 levels with clinicopathological data for patients with CRC showed that high EZH2 expression was positively associated with tumor depth of invasion (P = 0.000), vascular invasion (P = 0.001), lymphatic metastasis (P = 0.000), TNM stage (P = 0.000) and Ki67 immunostaining (P = 0.000; Table 1). Here, EZH2 is linked to neoplasm.