Meanwhile, administration of 14,15-EET or improving the level of EETs via suppressing sEH reduced cell apoptosis, inflammatory response, and oxidative stress by GSK3β-mediated p53, NF-κB, and Nrf2 signaling pathways in the kidney and central nervous system diseases 51, 59, 61, such as AKI, Parkinson's and Alzheimer's diseases. This evidence concerns the gene NFE2L2 and Alzheimer disease.