Meanwhile, administration of 14,15-EET or improving the level of EETs via suppressing sEH reduced cell apoptosis, inflammatory response, and oxidative stress by GSK3β-mediated p53, NF-κB, and Nrf2 signaling pathways in the kidney and central nervous system diseases 51, 59, 61, such as AKI, Parkinson's and Alzheimer's diseases. Here, NFE2L2 is linked to central nervous system disorder.