Moreover, exosomal circUSP7 was reported to induce CD8 + T cell dysfunction and anti-PD1 resistance by regulating the miR-934/ SH2 containing protein tyrosine phosphatase-2 (SHP2) axis in non-small cell lung cancer (NSCLC) 51. The gene discussed is PTPN11; the disease is non-small cell lung carcinoma.