Lee, H.-C., et al. found that exosomal yes1 associated transcriptional regulator (YAP1) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) facilitated the development of enzalutamide resistance through the induction of cancer stemness and lipid metabolism in prostate cancer 102 (Fig. 2C). This evidence concerns the gene YAP1 and Familial prostate cancer.