Lee, H.-C., et al. found that exosomal yes1 associated transcriptional regulator (YAP1) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) facilitated the development of enzalutamide resistance through the induction of cancer stemness and lipid metabolism in prostate cancer 102 (Fig. 2C). Here, YAP1 is linked to prostate carcinoma.