CNR1 and metabolic dysfunction-associated steatotic liver disease: In addition to the widely known myriocin, researchers have identified various other SPT inhibitors such as 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene] -thiazolidine-2, 4-dione (K145), cannabinoid-1- receptor (CB1R), etc. In NAFLD, K145 significantly improved fat accumulation in the liver of mice, and more importantly, it had no effect on lipid accumulation in normal liver 153, 154.