A study exploring the role of CD36 in lipid metabolism revealed that localization of CD36 on the plasma membranes of hepatocytes and CD36 palmitoylation are markedly increased in the liver of mice with NASH, which promotes free fatty acid uptake by hepatocytes and inhibits fatty acid β-oxidation, leading to intracellular lipid accumulation and increased inflammatory response. The gene discussed is CD36; the disease is metabolic dysfunction-associated steatohepatitis.