In Asah2-/- mice using a combination of dietary models of NAFLD/NASH, IgA secretion levels were altered in the intestine of Asah2-/- mice compared to control mice, leading to increased synthesis of IgA-associated bacteria and their derivatives, decreased inhibition of sphingolipid synthesis, and improved hepatic inflammatory response 140. This evidence concerns the gene ASAH2 and metabolic dysfunction-associated steatohepatitis.