Cui and his colleagues also found that ESM1 was a significant biomarker and negatively correlated with OS for multiple cancer types, including adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), ESCC, glioblastoma multiforme (GBM), kidney renal papillary cell carcinoma (KIRP), sarcoma (SARC) and uterine corpus endometrial carcinoma (UCEC) 15. This evidence concerns the gene ESM1 and cervical squamous cell carcinoma.