In colon cancer, KMT2B contributed to increased cancer stemness and decreased chemosensitivity via enhancing the expression of leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), which is a composition of the Wnt receptor complex, by maintaining H3K4me3 at the promoter region of LGR5 gene 21. This evidence concerns the gene KMT2B and colonic neoplasm.