Asuthkar et al. reported that nuclear translocation of HAND1 is directly regulated by uPAR protein, which controls medulloblastoma angiogenesis; HAND1 expression attenuates epithelial-mesenchymal transition (EMT) and inhibits medulloblastoma cell invasion and metastasis via Oct-3/4/β-catenin interaction 20-22. This evidence concerns the gene PLAUR and medulloblastoma.